Any 32 or 64 Bit OS that runs on a Raspberry Pi 4 will run on the Pi-Cube.
Third-party operating systems are available for download via the official Raspberry Pi website (see link below). The Pi can run a large range of systems, including the official Raspbian OS, Ubuntu Mate, Snappy Ubuntu Core, the Kodi-based media centers OSMC and LibreElec, and many more.
Useful Links